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FEMALE REPRODUCTIVE TRACT TUMORS : Original Article
doi:
10.4103/2278-330X.126520
Serum zinc as a prognostic indicator in locally advanced cancer cervix patients receiving chemo-irradiation: A pilot study
1
Department of Radiation Oncology, Artemis Health Institute, Sector 51, Gurgaon, Haryana
2
Department of Radiation Oncology, AIIMS, New Delhi
3
Department of Radiation Oncology, RGCI and RC, New Delhi
*Corresponding author: Dr. Vivek Tiwari. dr_vivektiwari@rediffmail.com
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Disclaimer:
This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.
This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.
Abstract
Abstract
Objective: To evaluate the prognostic significance of serum Zinc (S.Zn) in locally advanced cancer cervix (LACC) patients treated with chemo-irradiation. Materials and Methods: S.Zn values in 34 females with histopathologically (HP) proven LACC (>/= stage II B) were prospectively measured using atomic absorption spectrophotometer pre- and post-treatment. Thirty-four age- and sex-matched healthy individuals were also evaluated for the parameter during the course of the study. After completion of treatment, the patients were divided into 2 groups based on the response, 1 - Complete response (CR) and 2 - Partial/No response (PR/NR). These groups were compared based on the observations of the studied parameter. Results: The mean post-treatment S.Zn values were significantly higher in group 1 as compared to group 2 (P < 0.05). Conclusion: In our study, patients achieving CR had higher mean levels of S.Zn compared to patients achieving PR/NR. We advocate further in-depth studies to evaluate the role of S.Zn in the prognosis of LACC patients treated with chemo-irradiation.
Keywords
References
- Yasmeen J, Qurieshi MA, Manzoor NA, Asiya W, Ahmad SZ. Community-based screening of cervical cancer in a low prevalence area of India: A cross sectional study. Asian Pac J Cancer Prev 2010;11:231-4.
- Geara FB, Shamseddine A, Khalil A, Abboud M, Charafeddine M, Seoud M. A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer. Radiat Oncol 2010,5:84.
- McNeil C. New standard of care for cervical cancer sets stage for next questions. J Natl Cancer Inst 1999;91:500-1.
- Au-Yeung G, Mileshkin L, Bernshaw DM, Kondalsamy-Chennakesavan S, Rischin D, Narayan K. Radiation with cisplatin or carboplatin for locally advanced cervix cancer: The experience of a tertiary cancer centre. J Med Imaging Radiat Oncol 2013;57:97-104.
- Grail A, Norval M. Copper and zinc levels in serum from patients with abnormalities of the uterine cervix. Acta Obstet Gynecol Scand 1986;65:443-7.
- Gumulec J, Masarik M, Krizkova S, Adam V, Hubalek J, Hrabeta J, et al. Insight to physiology and pathology of zinc (II) ions and their actions in breast and prostate carcinoma. Curr Med Chem 2011;18:5041-51.
- Formigari A, Gregianin E, Irato P. The effect of zinc and the role of p53 in copper-induced cellular stress responses. J Appl Toxicol 2013;33:527-36.
- Chakravarty PK, Ghosh A, Chowdhury JR. Zinc in human malignancies. Neoplasma 1986;33:85-90.
- Marczyñska A, Adamczyk B, Medvey W. Serum levels of copper, iron and zinc and electrophoretic protein patterns in patients with cervical carcinoma. Nowotwory 1976;26:217-23.
- Kalasiewicz M, Wojcik-Janiszek J. Zinc content in granulocytes of patients with breast and cervical carcinoma following radiotherapy. Pol Tyg Lek 1977;32:145-6.
- Cunzhi H, Jiexian J, Xianwen Z, Jingang G, Shumin Z, Lili D. Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma. Biol Trace Elem Res 2003;94:113-22.
- Rybnikov VI. Trace element content in the blood and tissues of patients with precancerous and precursor diseases of the female genitalia. Vopr Onkol 1985;31:18-21.
- Lanciano RM, Pajak TF, Martz K, Hanks GE. The influence of treatment time on outcome for squamous cell cancer of the uterine cervix treated with radiation: A patterns-of-care study. Int J Radiat Oncol Biol Phys 1993;25:391-7.
- Peters WA, Liu PY, Barrett RJ, Stock RJ, Monk BJ, Berek JS, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 2000;18:1606-13.
- Negi RR, Gupta M, Kumar M, Gupta MK, Seam R, Rastogi M. Concurrent chemoradiation in locally advanced carcinoma cervix patients. J Cancer Res Ther 2010;6:159-66.
- Marnitz S, Budach V, Weißer F, Burova E, Gebauer B, Vercellino FG, et al. Rectum separation in patients with cervical cancer for treatment planning in primary chemo-radiation. Radiat Oncol 2012;7:109.
- Ji JH, Shin DG, Kwon Y, Cho DH, Lee KB, Park SS, et al. Clinical correlation between gastric cancer type and serum selenium and zinc levels. J Gastric Cancer 2012;12:217-22.
- Zowczak M, Iskra M, Torliñski L, Cofta S. Analysis of serum copper and zinc concentrations in cancer patients. Biol Trace Elem Res 2001;82:1-8.
- Xiao H, Jiang Y, Qi Y, Zhou X, Gong C, Huang C, et al. Effects of selenium and zinc on the proliferation of human esophageal cancer cell line studied by serophysiology. Wei Sheng Yan Jiu 2012;41:185-90.
- Cunzhi H, Jiexian J, Xianwen Z, Jingang G, Shumin Z, Lili D. Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma. Biol Trace Elem Res 2003;94:113-22.
- Grail A, Norval M. Copper and zinc levels in serum from patients with abnormalities of the uterine cervix. Acta Obstet Gynecol Scand 1986;65:443-7.
- Gao ZJ. Diagnostic value of serum copper/zinc ratio in gynecologic tumors. Zhonghua Zhong Liu Za Zhi 1988;10:434-6.
- Wang S, Avery JE, Hannafon BN, Lind SE, Ding WQ. Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: The involvement of the Wnt/β-catenin signaling pathway. Biochem Pharmacol 2013;85:1611-8.
- Prasad AS. Discovery of human zinc deficiency: Its impact on human health and disease. Adv Nutr 2013;4:176-90.