Radiotherapy-enhanced ototoxicity in elderly

Monika S. Malgonde; Manoj Kumar

doi:10.4103/2278-330X.142982

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TREATMENT TOXICITY : Original Article

03 (

); 221-222

doi:

10.4103/2278-330X.142982

Radiotherapy-enhanced ototoxicity in elderly

Monika S. Malgonde^1,, Manoj Kumar²

1 Department of Ear, Nose and Throat, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha

2 Department of Orthopaedics, Lilavati Hospital and Research Centre, Bandra, Mumbai, Maharashtra

*Corresponding author: Dr. Monika S. Malgonde. monika@mgims.ac.in

Published: 2020-12-31

MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Abstract

Introduction: Most head and neck cancers occur in elderly age and there is a natural occurrence of sensorineural hearing loss (SNHL) due to age also. Despite the ages and the physiological changes inherent to ageing, their auditory systems when exposed to aggressive agents caused the hearing loss to be greater as a consequence of the treatment received. Materials and Methods: Histopathologically proved 66 head and neck cancer patients were subjected to radiotherapy (RT) and 34 patients were subjected to concomitant chemoradiation (RT + CT) to study the occurrence of SNHL from 1 ^st September 2010 to 31 ^st August 2012. Result: It was found that the percentage of significant SNHL was more in patients >50 years after RT and RT + CT. It was also found that the results were significant. Conclusion: The occurrence of SNHL is more in elderly and the concern for the quality of life of patients undergoing cancer treatment is necessarily growing. Hence, the determination of hearing loss should be a part of investigations to enable better rehabilitation in elderly.

Keywords

References

Schultz C, Goffi-Gomez MV, Pecora Liberman PH, Pellizzon AC, Carvalho AL. Hearing loss and complaint in patients with head and neck cancer treated with radiotherapy. Arch Otolaryngol Head Neck Surg 2010;136:1065-9.
Kwong DL, Wei WI, Sham JS, Ho WK, Yuen PW, Chua DT, et al. Sensorineural hearing loss in patients treated for nasopharyngeal carcinoma: A prospective study of the effect of radiation and cisplatin treatment. Int J Radiat Oncol Biol Phys 1996;36:281-9.
Li JJ, Guo YK, Tang QL, Li SS, Zhang XL, Wu PA, et al. Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma. J Laryngol Otol 2010;124:32-6.
Petsuksiri J, Sermsree A, Thephamongkhol K, Keskool P, Thongyai K, Chansilpa Y, et al. Sensorineural hearing loss after concurrent chemoradiotherapy in nasopharyngeal cancer patients. Radiat Oncol 2011;6:19.
Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R. Radiotherapy-induced ear toxicity. Cancer Treat Rev 2003;29:417-30.
Low WK, Tan MG, Chua AW, Sun L, Wang DY. 12th Yahya Cohen Memorial Lecture: The cellular and molecular basis of radiation-induced sensori-neural hearing loss. Ann Acad Med Singapore 2009;38:91-4.
Bhandare N, Antonelli PJ, Morris CG, Malayapa RS, Mendenhall WM. Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys 2007;67:469-79.
Herrmann F, Dorr W, Muller R, Herrmann T. A prospective study on radiation-induced changes in hearing function. Int J Radiat Oncol Biol Phys 2006;65:1338-44.
Walker DA, Pillow J, Waters KD, Keir E. Enhanced cis-platinum ototoxicity in children with brain tumours who have received simultaneous or prior cranial irradiation. Med Pediatr Oncol 1989;17:48-52.

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[1] Schultz C, Goffi-Gomez MV, Pecora Liberman PH, Pellizzon AC, Carvalho AL. Hearing loss and complaint in patients with head and neck cancer treated with radiotherapy. Arch Otolaryngol Head Neck Surg 2010;136:1065-9.

[2] Kwong DL, Wei WI, Sham JS, Ho WK, Yuen PW, Chua DT, et al. Sensorineural hearing loss in patients treated for nasopharyngeal carcinoma: A prospective study of the effect of radiation and cisplatin treatment. Int J Radiat Oncol Biol Phys 1996;36:281-9.

[3] Li JJ, Guo YK, Tang QL, Li SS, Zhang XL, Wu PA, et al. Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma. J Laryngol Otol 2010;124:32-6.

[4] Petsuksiri J, Sermsree A, Thephamongkhol K, Keskool P, Thongyai K, Chansilpa Y, et al. Sensorineural hearing loss after concurrent chemoradiotherapy in nasopharyngeal cancer patients. Radiat Oncol 2011;6:19.

[5] Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R. Radiotherapy-induced ear toxicity. Cancer Treat Rev 2003;29:417-30.

[6] Low WK, Tan MG, Chua AW, Sun L, Wang DY. 12th Yahya Cohen Memorial Lecture: The cellular and molecular basis of radiation-induced sensori-neural hearing loss. Ann Acad Med Singapore 2009;38:91-4.

[7] Bhandare N, Antonelli PJ, Morris CG, Malayapa RS, Mendenhall WM. Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys 2007;67:469-79.

[8] Herrmann F, Dorr W, Muller R, Herrmann T. A prospective study on radiation-induced changes in hearing function. Int J Radiat Oncol Biol Phys 2006;65:1338-44.

[9] Walker DA, Pillow J, Waters KD, Keir E. Enhanced cis-platinum ototoxicity in children with brain tumours who have received simultaneous or prior cranial irradiation. Med Pediatr Oncol 1989;17:48-52.

Radiotherapy-enhanced ototoxicity in elderly

Abstract

Abstract

Keywords

References

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