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None
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Original Article
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Original Article: Bone and Soft Tissue Cancers
Original Article: Bone and Soft Tissue Tumor
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ORIGINAL ARTICLE: Brain Tumors
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ORIGINAL ARTICLE: Gynaecological Cancers
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Original Article: Hematolymphoid Malignancy
Original Article: Hepatobiliary Cancer
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Original Article: Leukemia -Lymphoma and Myeloma
ORIGINAL ARTICLE: Leukemia, Lymphoma & Plasma Cell Disorder
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ORIGINAL ARTICLE: Lung Cancers
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Original Article: Paediatric Cancer
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ORIGINAL ARTICLE: Sarcomas
ORIGINAL ARTICLE: Sarcomas and Skin Cancer
Original Article: Skin Cancer
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Original Research Article
PEDIATRIC ONCOLOGY : Original Article
PEDIATRIC SECTION: Editorial
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Pictorial CME, Haematological
Poetry in Oncology
Position Paper
QUEST FOR AN ANTIDOTE TO RADIATION TOXICITY : Editorial
QUEST FOR AN ANTIDOTE TO RADIATION TOXICITY : Original Article
RCC Practical Consensus Recommendations
Regional Article
Review Article
Review Article, Breast
Review Article, Haematological
Review Article, International
SARCOMA : Original Article
SARCOMA Review Article
SOFT TISSUE SARCOMA : Original Article
South Asia update
SOUTH ASIAN UPDATE : An update
SOUTH ASIAN UPDATE : Original Article
TABACCO, THE MENACE : Original Article
THE CUTTING EDGE OF RADIOTHERAPEUTICS : Editorial
THE CUTTING EDGE OF RADIOTHERAPEUTICS : Original Article
THE GREAT DEBATE: Against HPV vaccine in cervical cancer
THE GREAT DEBATE: AGAINST IMATINIB AS THE FIRST LINE TKI CHOICE FOR CML
THE GREAT DEBATE: Editorial-HPV vaccine in cervical cancer
THE GREAT DEBATE: For HPV vaccine in cervical cancer
THE GREAT DEBATE: FOR IMATINIB AS THE FIRST LINE TKI CHOICE FOR CML
THE GREY-HAIRED CANCER PATIENT: Editorial
THE GREY-HAIRED CANCER PATIENT: Original Article
THE SKILLFUL SCALPEL: Editorial
THE SKILLFUL SCALPEL: Original Article
THE WAR ON MICROBES: Editorial
THE WAR ON MICROBES: Original Article
THROUGH THE MICROSCOPE : Original Article
THROUGH THE MICROSCOPE: Editorial
TREATMENT TOXICITY : Original Article
TRENDS IN HORMONAL THERAPY IN PROSTATE CANCER: Review Article
URO-ONCOLOGY : Original Article
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Original Article
07 (
02
); 123-126
doi:
10.4103/sajc.sajc_117_18

Practical consensus recommendations regarding the management of hormone receptor positive early breast cancer in elderly women

Department of Medical Oncology, KMIO, Bengaluru, Karnataka
Department of Surgical Oncology, Max Hospital, New Delhi
Department of Radiation Oncology, Max Hospital, New Delhi
Department of Medical Oncology, Sarvodaya Hospital, Faridabad, Haryana
Department of Radiation Oncology, Ram Murti Medical College, Bareilly, Uttar Pradesh
Department of Medical Oncology, Bombay Hospital, Mumbai, Maharashtra
Department of Surgery, Sir Ganga Ram Hospital, New Delhi
Department of Radiation Oncology, RGCI, New Delhi
Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi
Department of Oncology, Shalby Cancer and Research Institute, Mumbai, Maharashtra

*Corresponding author: Dr. Govind Babu. kgblaugh@gmail.com

Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Disclaimer:
This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.

Abstract

Abstract

Breast cancer is a leading cause of death among women, and its incidence increases with age. Currently the treatment of breast cancer in older patients is almost identical to their younger counterparts. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at these practical consensus recommendations for the benefit of community oncologists regarding the management of early breast cancer specifically in elderly women.

Keywords

PubMed

References

  1. NCRP – Three Year Report of the Population Based Cancer Registries 2012 – 2014, National Cancer Registry Programme. Bangalore: Indian Council of Medical Research; 2016.
  2. NNCRP – Consolidated Report of the Hospital Based Cancer Registries 2012 – 2014, National Cancer Registry Programme. Bangalore: Indian Council of Medical Research; 2016.
  3. Kiderlen M, Bastiaannet E, Walsh PM, Keating NL, Schrodi S, Engel J, et al. Surgical treatment of early stage breast cancer in elderly: An international comparison. Breast Cancer Res Treat 2012;132:675-82.
  4. Robertson JF, Todd JH, Ellis IO, Elston CW, Blamey RW. Comparison of mastectomy with tamoxifen for treating elderly patients with operable breast cancer. BMJ 1988;297:511-4.
  5. Gazet JC, Ford HT, Coombes RC, Bland JM, Sutcliffe R, Quilliam J, et al. Prospective randomized trial of tamoxifen vs. surgery in elderly patients with breast cancer. Eur J Surg Oncol 1994;20:207-14.
  6. International Breast Cancer Study Group, Rudenstam CM, Zahrieh D, Forbes JF, Crivellari D, Holmberg SB, et al. Randomized trial comparing axillary clearance versus no axillary clearance in older patients with breast cancer:First results of International Breast Cancer Study Group Trial 10-93. J Clin Oncol 2006;24:337-44.
  7. Martelli G, Miceli R, Daidone MG, Vetrella G, Cerrotta AM, Piromalli D, et al. Axillary dissection versus no axillary dissection in elderly patients with breast cancer and no palpable axillary nodes: Results after 15 years of follow-up. Ann Surg Oncol 2011;18:125-33.
  8. Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, et al. Axillary dissection vs. no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial. JAMA 2011;305:569-75.
  9. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347:1233-41.
  10. Fyles AW, McCready DR, Manchul LA, Trudeau ME, Merante P, Pintilie M, et al. Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 2004;351:963-70.
  11. Hughes KS, Schnaper LA, Berry D, Cirrincione C, McCormick B, Shank B, et al. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 2004;351:971-7.
  12. Smith BD, Gross CP, Smith GL, Galusha DH, Bekelman JE, Haffty BG, et al. Effectiveness of radiation therapy for older women with early breast cancer. J Natl Cancer Inst 2006;98:681-90.
  13. Smith BD, Haffty BG, Hurria A, Galusha DH, Gross CP. Postmastectomy radiation and survival in older women with breast cancer. J Clin Oncol. 2006;24:4901–4907.
  14. Truong PT, Bernstein V, Lesperance M, Speers CH, Olivotto IA. Radiotherapy omission after breast-conserving surgery is associated with reduced breast cancer-specific survival in elderly women with breast cancer. Am J Surg 2006;191:749-55.
  15. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005;366:2087-106.
  16. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Darby S, McGale P, Correa C, Taylor C, Arriagada R, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 2011;378:1707-16.
  17. Tamoxifen for early breast cancer: An overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet 1998;351:1451-67.
  18. VanderWalde A, Hurria A. Early breast cancer in the older woman. Clin Geriatr Med 2012;28:73-91.
  19. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005;365:1687-717.
  20. Crivellari D, Price K, Gelber RD, Castiglione-Gertsch M, Rudenstam CM, Lindtner J, et al. Adjuvant endocrine therapy compared with no systemic therapy for elderly women with early breast cancer: 21-year results of International Breast Cancer Study Group Trial IV. J Clin Oncol 2003;21:4517-23.
  21. Polychemotherapy for early breast cancer: An overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet 1998;352:930-42.
  22. Burdette-Radoux S, Muss HB. Adjuvant chemotherapy in the elderly: Whom to treat, what regimen? Oncologist 2006;11:234-42.
  23. Muss HB, Berry DA, Cirrincione CT, Theodoulou M, Mauer AM, Kornblith AB, et al. Adjuvant chemotherapy in older women with early-stage breast cancer. N Engl J Med 2009;360:2055-65.
  24. Giordano SH, Duan Z, Kuo YF, Hortobagyi GN, Goodwin JS. Use and outcomes of adjuvant chemotherapy in older women with breast cancer. J Clin Oncol 2006;24:2750-6.
  25. Elkin EB, Hurria A, Mitra N, Schrag D, Panageas KS. Adjuvant chemotherapy and survival in older women with hormone receptor-negative breast cancer: Assessing outcome in a population-based, observational cohort. J Clin Oncol 2006;24:2757-64.
  26. Berry DA, Cirrincione C, Henderson IC, Citron ML, Budman DR, Goldstein LJ, et al. Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA 2006;295:1658-67.
  27. Mungle T, Tewary S, Arun I, Basak B, Agarwal S, Ahmed R, et al. Automated characterization and counting of Ki-67 protein for breast cancer prognosis: A quantitative immunohistochemistry approach. Comput Methods Programs Biomed 2017;139:149-61.
  28. Dowsett M, Nielsen TO, A'Hern R, Bartlett J, Coombes RC, Cuzick J, et al. Assessment of Ki67 in breast cancer: Recommendations from the international Ki67 in breast cancer working group. J Natl Cancer Inst 2011;103:1656-64.
  29. Bertucci F, Birnbaum D. Reasons for breast cancer heterogeneity. J Biol 2008;7:6.
  30. Polyak K. Heterogeneity in breast cancer. J Clin Invest 2011;121:3786-8.
  31. Yersal O, Barutca S. Biological subtypes of breast cancer: Prognostic and therapeutic implications. World J Clin Oncol 2014;5:412-24.
  32. Munkácsy G, Szász MA, Menyhárt O. Gene expression-based prognostic and predictive tools in breast cancer. Breast Cancer 2015;22:245-52.
  33. de Azambuja E, Cardoso F, de Castro G Jr., Colozza M, Mano MS, Durbecq V, et al. Ki-67 as prognostic marker in early breast cancer: A meta-analysis of published studies involving 12,155 patients. Br J Cancer 2007;96:1504-13.
  34. Sharma S, Hiran KR, Pavithran K, Vijaykumar DK. A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day and 21 days after first cycle of chemotherapy in carcinoma of breast: A prospective non-randomized observational study. World J Surg Oncol 2009;7:35.
  35. Bottini A, Berruti A, Bersiga A, Brizzi MP, Bruzzi P, Aguggini S, et al. Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer. Br J Cancer 2001;85:1106-12.
  36. Bottini A, Berruti A, Bersiga A, Brunelli A, Brizzi MP, Marco BD, et al. Effect of neoadjuvant chemotherapy on Ki67 labelling index, c-erbB-2 expression and steroid hormone receptor status in human breast tumours. Anticancer Res 1996;16:3105-10.
  37. Ellis PA, Smith IE, Detre S, Burton SA, Salter J, A'Hern R, et al. Reduced apoptosis and proliferation and increased Bcl-2 in residual breast cancer following preoperative chemotherapy. Breast Cancer Res Treat 1998;48:107-16.
  38. Clarke RB, Laidlaw IJ, Jones LJ, Howell A, Anderson E. Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status. Br J Cancer 1993;67:606-11.
  39. Dardes RD, Horiguchi J, Jordan VC. A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer. Int J Oncol 2000;16:25-30.
  40. Makris A, Powles TJ, Allred DC, Ashley S, Ormerod MG, Titley JC, et al. Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response. Breast Cancer Res Treat 1998;48:11-20.
  41. Chang J, Powles TJ, Allred DC, Ashley SE, Clark GM, Makris A, et al. Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer. J Clin Oncol 1999;17:3058-63.
  42. Nielsen TO, Parker JS, Leung S, Voduc D, Ebbert M, Vickery T, et al. A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer. Clin Cancer Res 2010;16:5222-32.
  43. Chia SK, Bramwell VH, Tu D, Shepherd LE, Jiang S, Vickery T, et al. A 50-gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen. Clin Cancer Res 2012;18:4465-72.
  44. Martín M, Prat A, Rodríguez-Lescure A, Caballero R, Ebbert MT, Munárriz B, et al. PAM50 proliferation score as a predictor of weekly paclitaxel benefit in breast cancer. Breast Cancer Res Treat 2013;138:457-66.
  45. Cheang MC, Voduc KD, Tu D, Jiang S, Leung S, Chia SK, et al. Responsiveness of intrinsic subtypes to adjuvant anthracycline substitution in the NCIC.CTG MA.5 randomized trial. Clin Cancer Res 2012;18:2402-12.
  46. Jørgensen CL, Nielsen TO, Bjerre KD, Liu S, Wallden B, Balslev E, et al. PAM50 breast cancer intrinsic subtypes and effect of gemcitabine in advanced breast cancer patients. Acta Oncol 2014;53:776-87.

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