Fluoride levels and osteosarcoma

Simmi Kharb; Ravindra Sandhu; Zile Singh Kundu

doi:10.4103/2278-330X.103717

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Original Article

01 (

); 76-77

doi:

10.4103/2278-330X.103717

Fluoride levels and osteosarcoma

Simmi Kharb^1,, Ravindra Sandhu¹, Zile Singh Kundu²

1 Departments of Biochemistry, Pt.BDS PGIMS, Rohtak, India

2 Departments of Orthopedics, Pt.BDS PGIMS, Rohtak, India

*Corresponding author: Dr. Simmi Kharb. simmikh@rediffmail.com

Published: 2020-12-30

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Abstract

Context: Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma. Aims: The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water. Settings and Design: The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls). Materials and Methods: Serum and drinking water fluoride levels were estimated by ion selective electrode. Statistical analysis used: The data were computed as mean ± SD and Student’s t test was applied. Results: Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P < 0.05, P < 0.001, respectively). Conclusions: These results suggest a link between fluoride exposure and osteosarcoma.

Keywords

References

Lav KH, Baylink DJ. Molecular mechanism of action of fluoride on bone cells. J Bone Miner Res 1998;13:1660-7.
Operskalski EA, Martin SP, Henderson B, Vischer BR. A case control study of osteosarcoma in young persons. Am J Epidemiol 1987;126:118-9.
Susheela AK. A treatise on fluorosis. UNICEF 2003. Delhi. Fluorosis Research and Rural Development Foundation. Delhi-India: 2001. p. 15.
Bassin EB, Wypij D, Davis RB, Mittleman MA. Age specific fluoride exposure in drinking water and osteosarcoma. Cancer Causes Control 2006;17:421-8.
Hoover RN, Devsa SS, Cantor KP, Lubin JH, Fraumani JF. Time trends for bone and joint cancers and osteosarcomas in the surveillance, epidemiology and end results (SEER) program. In: National Cancer Institute. DHHS review of fluoride benefits and risks. US Public Health Service; 1990. p. F1-7.
Cohn PD. A brief report on the association of drinking water fluoridation and the incidence of osteosarcoma among young males. New Jersey: Department of Health: Environmental Health Service; 1992. p. 1-17.
Yiamouyiannis JA. Fluoridation and cancer. The biology and epidemiology of bone and oral cancer related to fluoridation. Fluoride 1993;26:83-96.
Mcguire SM, Vanable ED, Mcguire MH, Buckwalter JA, Douglass CW. Is there a link between fluoridated water and osteosarcoma? J Am Dent Assoc 1991;122:39-45.
Gelberg KH, Fitzgerald EF, Synian H, Robert D. Fluoride exposure and childhood osteosarcoma: A Case Control Study. Am J Public Health 1995;85:1678-83.
Freni SC, Gaylor DW. International trends in the incidence of bone cancer are not related to drinking water fluoridation. Cancer 1992;70:611-8.
Venkateswarlu P. Evaluation of analytical method for fluorine in biological and related materials. J Dent Res 1990;69:514-21.
Caverzasio J, Palmer G, Suzuki A, Bonjour JP. Mechanism of the mitogenic effect of fluoride on osteoblast-like cells; evidence for a G-protein dependent tyrosine phosphorylation process. J Bone Miner Res 1997;12:1975-83.
Sandhu R, Lal H, Kundu ZS, Kharb S. Serum fluoride and sialic acid levels in osteosarcoma. Biol Trace Elem Res 2011;144:1-5 (accepted).
Pasquini GM, Davey RA, Michelangeli VP, Grill V, Kaczmarczyk SJ, Zajac JD. Local secretion of parathyroid hormone related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition. Bone 2002;31:598-605.
Xiang QY, Liang YX, Chen BH, Wang CS, Zhen LQ, Chan LS, et al. Study on the application of benchmark dose and biological monitoring indexes of fluoride in drinking water. Zhonghua Yu Fang Yi Xue Za Zhi 2004;38:261-4.
Wergedal JE, Lau K-HW, Baylink DJ. Fluoride and bovine bone extract influence cell proliferation and phosphatase activities in human bone cell cultures. Clin Orthop Relat Res 1988;233:274-82.
Ramesh N, Vuayaraghavan AS, Desai BS, Natarajan M, Murthy PB, Pillai KS. Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. J Environ Pathol Toxicol Oncol 2001;20:237-43.

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[1] Lav KH, Baylink DJ. Molecular mechanism of action of fluoride on bone cells. J Bone Miner Res 1998;13:1660-7.

[2] Operskalski EA, Martin SP, Henderson B, Vischer BR. A case control study of osteosarcoma in young persons. Am J Epidemiol 1987;126:118-9.

[3] Susheela AK. A treatise on fluorosis. UNICEF 2003. Delhi. Fluorosis Research and Rural Development Foundation. Delhi-India: 2001. p. 15.

[4] Bassin EB, Wypij D, Davis RB, Mittleman MA. Age specific fluoride exposure in drinking water and osteosarcoma. Cancer Causes Control 2006;17:421-8.

[5] Hoover RN, Devsa SS, Cantor KP, Lubin JH, Fraumani JF. Time trends for bone and joint cancers and osteosarcomas in the surveillance, epidemiology and end results (SEER) program. In: National Cancer Institute. DHHS review of fluoride benefits and risks. US Public Health Service; 1990. p. F1-7.

[6] Cohn PD. A brief report on the association of drinking water fluoridation and the incidence of osteosarcoma among young males. New Jersey: Department of Health: Environmental Health Service; 1992. p. 1-17.

[7] Yiamouyiannis JA. Fluoridation and cancer. The biology and epidemiology of bone and oral cancer related to fluoridation. Fluoride 1993;26:83-96.

[8] Mcguire SM, Vanable ED, Mcguire MH, Buckwalter JA, Douglass CW. Is there a link between fluoridated water and osteosarcoma? J Am Dent Assoc 1991;122:39-45.

[9] Gelberg KH, Fitzgerald EF, Synian H, Robert D. Fluoride exposure and childhood osteosarcoma: A Case Control Study. Am J Public Health 1995;85:1678-83.

[10] Freni SC, Gaylor DW. International trends in the incidence of bone cancer are not related to drinking water fluoridation. Cancer 1992;70:611-8.

[11] Venkateswarlu P. Evaluation of analytical method for fluorine in biological and related materials. J Dent Res 1990;69:514-21.

[12] Caverzasio J, Palmer G, Suzuki A, Bonjour JP. Mechanism of the mitogenic effect of fluoride on osteoblast-like cells; evidence for a G-protein dependent tyrosine phosphorylation process. J Bone Miner Res 1997;12:1975-83.

[13] Sandhu R, Lal H, Kundu ZS, Kharb S. Serum fluoride and sialic acid levels in osteosarcoma. Biol Trace Elem Res 2011;144:1-5 (accepted).

[14] Pasquini GM, Davey RA, Michelangeli VP, Grill V, Kaczmarczyk SJ, Zajac JD. Local secretion of parathyroid hormone related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition. Bone 2002;31:598-605.

[15] Xiang QY, Liang YX, Chen BH, Wang CS, Zhen LQ, Chan LS, et al. Study on the application of benchmark dose and biological monitoring indexes of fluoride in drinking water. Zhonghua Yu Fang Yi Xue Za Zhi 2004;38:261-4.

[16] Wergedal JE, Lau K-HW, Baylink DJ. Fluoride and bovine bone extract influence cell proliferation and phosphatase activities in human bone cell cultures. Clin Orthop Relat Res 1988;233:274-82.

[17] Ramesh N, Vuayaraghavan AS, Desai BS, Natarajan M, Murthy PB, Pillai KS. Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. J Environ Pathol Toxicol Oncol 2001;20:237-43.

Fluoride levels and osteosarcoma

Abstract

Abstract

Keywords

References

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