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ORIGINAL ARTICLE: Hematolymphoid Malignancies
doi:
10.4103/sajc.sajc_249_19
Clinico-epidemiological features and response in childhood acute lymphoblastic leukemia at regional cancer center of Northeast India
1
Department of Medical Oncology, Dr. B Borooah Cancer Institute, Guwahati, Assam
2
Department of Pathology, Dr. B Borooah Cancer Institute, Guwahati, Assam
*Corresponding author: Prof. Bhargab Jyoti Saikia. bhargabjyotisaikia@gmail.com
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Disclaimer:
This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.
This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.
Abstract
Abstract
Introduction: Acute lymphoblastic leukemia (ALL) comprises 19.3% of all childhood cancers in Northeast India. Methods: We analyzed clinicoepidemiological features and early response to the treatment of all the cases of childhood ALL (age <15 years) diagnosed and treated at Dr. B Borooah Cancer Institute over 1 year. Results: Of 52 eligible cases, 69% were male (male:female ratio of 2.2:1) and the mean age was 7.1 years. Thirty-three children (63%) had baseline white blood cell count ≥20 × 109/L. Precursor B-cell was most the common subtype seen in 61% of children. Seven cases (14%) had high-risk (HR) cytogenetics, with t (9,22) being the most common one. Male sex and HR cytogenetics were significantly associated with poor early responses. Conclusion: ALL is a common childhood malignancy with high cure rates. However, poor socioeconomic status and the presence of higher proportions of disease-related factors lead to poor outcome in this part of the country.
Keywords
Acknowledgment
Authors are grateful to the Hospital-Based Cancer Registry (HBCR) of Dr. B Borooah Cancer Institute, Guwahati, Assam, for providing the data.
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