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Mini Symposium on CML
doi:
10.4103/2278-330X.96498
Chronic myeloid leukemia: In pursuit of perfection
1
Consultant Haemato-Oncologist, Kingston and Royal Marsden Hospitals, London, UK
*Corresponding author: Dr. Vishal Jayakar. vishal.jayakar@kingstonhospital.nhs.uk
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Disclaimer:
This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.
This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.
Abstract
Abstract
The resounding success of imatinib (IM) as front line treatment in patients with chronic myeloid leukemia (CML) has certainly made a paradigm shift in the therapeutic algorithm of this disorder. The precise targeting of the BCR-ABL oncogene in CML has entitled it to be the poster child of translational medicine with a well-deserved Oscar ovation from the oncology community. Clinicians are now empowered with first-, second- and third-generation tyrosine kinases, as well as advanced molecular tools to monitor disease and characterize resistance. We have come a long way in successfully managing these patients, but there are still a significant few unmet clinical needs which need addressing and targeting to optimize clinical outcomes. This review focuses on 4 such pertinent and relevant clinical issues, which still need ironing out to fulfill our ambition of achieving ‘perfection’ in this patient cohort.
Keywords
Acknowledgment
I am grateful to Dr Helen Sykes (Head of Hematology-Kingston Hospital) for critical evaluation of the manuscript.
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