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  Indian J Med Microbiol
 

Figure 2: Cumulative distribution plot of cost benefit comparing a three-step pathway with droplet digital polymerase chain reaction upfront versus a three-step pathway with immunohistochemistry upfront, with varying fixed costs of droplet digital polymerase chain reaction. A three-step pathway with DDPCR upfront could have higher cost benefit than a three-step pathway with immunohistochemistry upfront provided the cost of DDPCR was <0.5 times the cost of immunohistochemistry. When droplet digital polymerase chain reaction cost was fixed at 0.5 times the cost of immunohistochemistry, then the contribution of “clinical benefit of droplet digital polymerase chain reaction as a first-line test,” “clinical benefit of droplet digital polymerase chain reaction as a second-line test,” “clinical benefit of immunohistochemistry as a first-line test,” “clinical benefit of immunohistochemistry as a second-line test”, and “cost of fluorescent in situ hybridization” to the overall variance was 36%, 20.7%, 15.7%, 27.7%, and 0.47%, respectively. DDPCR=Droplet digital polymerase chain reaction

Figure 2: Cumulative distribution plot of cost benefit comparing a three-step pathway with droplet digital polymerase chain reaction upfront versus a three-step pathway with immunohistochemistry upfront, with varying fixed costs of droplet digital polymerase chain reaction. A three-step pathway with DDPCR upfront could have higher cost benefit than a three-step pathway with immunohistochemistry upfront provided the cost of DDPCR was <0.5 times the cost of immunohistochemistry. When droplet digital polymerase chain reaction cost was fixed at 0.5 times the cost of immunohistochemistry, then the contribution of “clinical benefit of droplet digital polymerase chain reaction as a first-line test,” “clinical benefit of droplet digital polymerase chain reaction as a second-line test,” “clinical benefit of immunohistochemistry as a first-line test,” “clinical benefit of immunohistochemistry as a second-line test”, and “cost of fluorescent <b>in situ</b> hybridization” to the overall variance was 36%, 20.7%, 15.7%, 27.7%, and 0.47%, respectively. DDPCR=Droplet digital polymerase chain reaction