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  Indian J Med Microbiol
 

Figure 1: Cumulative distribution plot of incremental cost-effectiveness difference with varying fixed costs of droplet digital polymerase chain reaction. Three-step pathway with droplet digital polymerase chain reaction as a second-line test would be more cost-effective than conventional pathway if cost of droplet digital polymerase chain reaction was <1.5 times the cost of immunohistochemistry. For higher costs, the probability lowered but remained encouraging. When droplet digital polymerase chain reaction cost was 1.25 times the cost of immunohistochemistry, then the contribution of “cost of fluorescent in situ hybridization” and “clinical benefit of droplet digital polymerase chain reaction as a second-line test” to the overall variance was 66.19% and 36.29%, respectively. ICER=Incremental cost-effectiveness ratio, DDPCR=Droplet digital polymerase chain reaction

Figure 1: Cumulative distribution plot of incremental cost-effectiveness difference with varying fixed costs of droplet digital polymerase chain reaction. Three-step pathway with droplet digital polymerase chain reaction as a second-line test would be more cost-effective than conventional pathway if cost of droplet digital polymerase chain reaction was <1.5 times the cost of immunohistochemistry. For higher costs, the probability lowered but remained encouraging. When droplet digital polymerase chain reaction cost was 1.25 times the cost of immunohistochemistry, then the contribution of “cost of fluorescent <b>in situ</b> hybridization” and “clinical benefit of droplet digital polymerase chain reaction as a second-line test” to the overall variance was 66.19% and 36.29%, respectively. ICER=Incremental cost-effectiveness ratio, DDPCR=Droplet digital polymerase chain reaction