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2014| April-June | Volume 3 | Issue 2
Online since
April 14, 2014
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BREAST CANCER - REVIEW ARTICLE
Late effects of cancer treatment in breast cancer survivors
Sushma Agrawal
April-June 2014, 3(2):112-115
DOI
:10.4103/2278-330X.130445
PMID
:24818106
Postoperative radiation therapy (RT) and chemotherapy,both reduces the risk of local recurrence and extends overall survival in patients with breast cancer (BC). Concerns have, however, been raised about the risk of acute and chronic side effects in breast cancer survivors as the number of treated individuals is large and their expected survival is long compared to most patients with other malignant diseases. Cardiac toxicity, reproductive dysfunction, pneumonitis (RP),arm lymph edema, neuropathy, skin changes are examples of the wide range of complications that has been associated with adjuvant treatment.
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503
16
BREAST CANCER - ORIGINAL ARTICLES
Age at diagnosis of female breast cancer in Oman: Issues and implications
Itrat Mehdi, Essam Abdul Monem, Bassim Jaffar Al Bahrani, Suad Al Kharusi, Ayman Mohammad Nada, Jawad Al Lawati, Najla Al Lawati
April-June 2014, 3(2):101-106
DOI
:10.4103/2278-330X.130442
PMID
:24818104
Introduction:
Female breast cancer (BC) is the most frequent malignancy diagnosed globally, about 23% of the diagnosed cancers. BC incidence varies geographically, highest in Western Europe and lowest in Africa. BC in females is strongly correlated to age, the highest incidence rate amongst older women reinforcing the importance of hormonal status. BC in young females has an aggressive phenotype. There is a shared observation amongst practicing oncologists that BC in Middle East and the developing world presents at an earlier age.
Aim and Objective:
The aims of this study are to evaluate the age at presentation of female BC in Oman, and to compare our data with international and regional published data. It discusses the impact of young age Breast Cancer.
Materials and Methods:
All diagnosed female BC cases registered from 1996-2010 all over the country, were retrieved from the National Cancer Registry, Ministry of Health. BC cases were analyzed with respect to age at presentation. The data were compared with regional and international data.
Results:
A total of 14,109 cancer cases were recorded during the period of study. BC was the leading malignancy as 1,294 cases (9.1%). Female BC patients were 1,230; denoting 19.2% of all female cancers. 53.5% of female BC presented below 50 years of age. Male BC constituted 5% of total, with 67% of male BC occurring over 50 years of age. Compared with data from Oman, the highest rates in UK and other Western countries are above 50 years of age. These rates are four to 10 times higher than local in different age groups. Interestingly, these rates increase with increasing age in UK from 40-45 to up to 85+, keep on increasing and go up to four times higher with higher age. This phenomenon, of increasing incidence rates with age, is not observed in our local population.
Discussion:
BC is significantly correlated to age as reported from Western population. BC is reported at a younger age from developing and Arab World, which need to be further studied and validated. This phenomenon of BC in younger age may have significant implications and effects ranging from screening, diagnosis, management, prognosis, and cost of treatment.
Conclusion:
The impact on young women diagnosed with BC is enormous, ranging from psychosocial to healthcare services and economics. There is a need to study it further in depth in developing World.
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SOUTH ASIAN UPDATE - ORIGINAL ARTICLES
Breaking bad news of cancer diagnosis - Perception of the cancer patients in a rural community in Malaysia
Mathew Gabriel Bain, Cheah Whye Lian, Chang Ching Thon
April-June 2014, 3(2):116-121
DOI
:10.4103/2278-330X.130447
PMID
:24818107
Context:
Breaking of bad news is an important component in the management of cancer patients.
Aims:
This study aimed to assess the perceptions of breaking bad news of cancer diagnosis.
Settings and Design:
It was a cross-sectional study using Breaking Bad News Assessment Schedule (BAS) questionnaire on cancer patients in Serian district.
Materials and Methods:
Using snowballing sampling method, a total of 134 patients were interviewed face-to-face after the consent was obtained from each of the respondents.
Statistical Analysis Used:
Data was entered and analyzed using SPSS version 19.0.
Results:
Majority were comfortable with the current method of breaking bad news. The main aspects found to be the areas of concern were the importance of the usage of body language, management of time and identifying patients' key area of concerns. There were significant difference between sex and "information giving" (
P
= 0.028) and "general consideration" (
P
= 0.016) and also between "the age and setting the scene" (
P
= 0.042). Significant difference was also found between the types of cancer and "the setting of scene" (
P
= 0.018), "breaking bad news technique" (
P
= 0.010), "eliciting concerns" (
P
= 0.003) and "information giving" (
P
= 0.004).
Conclusion:
Good and effective communication skill of breaking bad news is vital in the management of cancer patients. As the incidence of new cases of cancer increase every year, breaking of bad news has become a pertinent to the medical professionals' role. Specific aspects of communication skills based on local characteristics should be more emphasized in the formulation of training for doctors.
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1
BREAST CANCER - ORIGINAL ARTICLES
Breast carcinoma in young females below the age of 40 years: A histopathological perspective
Shitalmala Thangjam, Rajesh Singh Laishram, Kaushik Debnath
April-June 2014, 3(2):97-100
DOI
:10.4103/2278-330X.130441
PMID
:24818103
Background:
Breast cancer among young women is a rare pathology, but is known to have a more aggressive behavior and poorer outcome.
Aims:
The objective of this study was to evaluate the clinicopathological characteristics of breast carcinoma below 40 years in comparison to that over 40 years in Manipur, India.
Settings and Design:
This retrospective study from the period of January 2005-December 2010 was conducted in the Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur.
Materials and Methods:
All cases of mastectomy specimens of carcinoma breast from the period of January 2005-December 2010 were included in the study. Clinical and histopathological data of all cases were reviewed and correlated.
Results:
A total of 507 mastectomy specimens were received, among which, 160 cases (31.56%) were below 40 years; whereas 347 cases (68.44%) were above 40 years of age. Stage III was the commonest stage (47% versus 18%) in the younger group; while in the older group, Stage II was the commonest (64% versus 34%).
Conclusion:
This study shows that young females with breast cancer have higher stage of tumor.
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5
SOUTH ASIAN UPDATE - ORIGINAL ARTICLES
Barriers for early detection of cancer amongst Indian rural women
Neha Tripathi, Yugantara R Kadam, Randhir V Dhobale, Alka D Gore
April-June 2014, 3(2):122-127
DOI
:10.4103/2278-330X.130449
PMID
:24818108
Context:
Breast and cervical cancer are the most common causes of cancer mortality among women worldwide, but actually they are largely preventable diseases. Healthcare providers in developing countries regularly see women with advanced, incurable cancers. Health of a rural Indian women and her access to health facility is compromised due to sociocultural, economical, and environmental factors.
Aims:
To know the problems associated with early detection of cancers in rural women.
Settings and Design:
Rural area and cross-sectional.
Subjects and Methods:
Study subject: Women of 35 years and above. Exclusion criteria: Not willing to participate. Sample size: All eligible women of selected villages.
Sampling Technique:
Random selection of villages. Study duration: 2 months. Study tools: Pretested questionnaire.
Statistical Analysis Used:
Percentages, χ
2
test, analysis of variance (ANOVA), multivariate analysis.
Results:
Awareness about symptoms, possibility of early detection, available tests, possibility of cure of disease was low. Main barrier for screening was cognitive, that is, 'don't know' answer by 83.99% women for cancer cervix, 84.93%, for cancer breast, and 67.26% for oral cancer. Awareness score was significantly associated with age (χ
2
= 17.77,
P
= 0.001), education (χ
2
= 34.62,
P
= 0.000), and income (χ
2
= 16.72,
P
= 0.002); while attitude score with age (χ
2
= 16.27,
P
= 0.012) and education (χ
2
= 25.16,
P
= 0.003). Practice score was significantly associated with age (χ
2
= 11.28,
P
= 0.023), education (χ
2
= 32.27,
P
= 0.003), and occupation (χ
2
= 10.69,
P
= 0.03). Awareness, attitude, and practice score of women having history of cancer in family or relative was significantly high than women without history.
Conclusions:
Cognitive barrier was the important barrier which has to be taken care of.
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1,675
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9
BREAST CANCER - ORIGINAL ARTICLES
Evaluation of protective effect of myricetin, a bioflavonoid in dimethyl benzanthracene-induced breast cancer in female Wistar rats
JK Jayakumar, P Nirmala, BA Praveen Kumar, Ashok P Kumar
April-June 2014, 3(2):107-111
DOI
:10.4103/2278-330X.130443
PMID
:24818105
Background:
Breast cancer is one of the most common cancers worldwide. Alarmingly, the incidence of breast cancer is rising rapidly in India.
Aim:
The present research was focused to assess the role of myricetin; a bioflavonoid in 7,12-dimethylbenzanthracene (DMBA)-induced breast cancer in female Wistar rats.
Materials and Methods:
A total of 36 female Wistar rats (total 6 groups,
n
= 6 per group) 6 - 8 weeks old, weighing 150 gm were used in the study. DMBA was given at the dose of 7.5 mg/kg subcutaneously in the mammary region once a week for 4 consecutive weeks in group 2. Vincristine was given in the dose of 500 μg/kg intraperitonially every week for 4 consecutive weeks in group 3. Myricetin was given orally in a dose of 50, 100, and 200 mg/kg in group 4, 5, and 6 respectively. The statistical significance of the data was determined using one way analysis of variance and Duncan's multiple range test.
Results:
The result showed that myricetin increased the antioxidant levels in plasma, erythrocyte lysate, and breast tissue and was effective in preventing the oxidative damage induced by the carcinogen DMBA. Myricetin 50, 100, and 200 mg/kg/oral for 120 days treated animal resulted comparable results to that of standard vincristine and control groups.
Conclusions:
Myricetin was found to be either equieffective or more effective than vincristine in all the parameters studied. Myricetin proved the capacity of flavonols to act as antioxidant in cells represents a potential treatment in the field of oncology.
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1,593
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9
CASE REPORT
Role of Crizotinib in previously treated non-small-cell lung cancer
Sunil Kumar Gupta
April-June 2014, 3(2):138-140
DOI
:10.4103/2278-330X.130468
PMID
:24818111
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3
SOUTH ASIAN UPDATE - ORIGINAL ARTICLES
Ramosetron hydrochloride for the prevention of cancer chemotherapy induced nausea and vomiting: The Indian experience
Jayesh J Sanmukhani, Prafulla Pawar, Ravindra Mittal
April-June 2014, 3(2):132-137
DOI
:10.4103/2278-330X.130466
PMID
:24818110
Background:
Despite the advent of 5-HT
3
antagonists, control of delayed gastrointestinal adverse events with cancer chemotherapy is still not optimal. This open label, active controlled, multicentric clinical trial was undertaken to assess the comparative efficacy and safety of ramosetron with ondansetron for the prevention of acute and delayed nausea and vomiting associated with emetogenic cancer chemotherapy in adult patients in India.
Materials and Methods:
Enrolled patients received treatment with ramosetron hydrochloride 0.1 mg or ondansetron hydrochloride 4 mg tablets once daily in the morning for 5 days starting 1 h before the start of chemotherapy. Severity grades of nausea and vomiting were recorded on a daily basis for a period of 5 days and complete response rate (CRR) and effective rate (ER) were calculated. Clinical adverse events were recorded and hematological and biochemical investigations were performed for safety assessment.
Results:
A total of 114 patients in ramosetron group and 100 patients in ondansetron group completed the study and were eligible for efficacy and safety analysis. CRR and ERs show that while ramosetron is non-inferior to ondansetron in the control of early nausea and vomiting (occurring during the first 24 h) after the treatment with emetogenic chemotherapy, it is superior to ondansetron in the control of delayed nausea and vomiting (occurring after the first 24 h). The proportion of patients achieving a cumulative complete response (for the entire study period) is significantly greater in ramosetron group as compared to ondansetron group (27.2% vs. 7.0%;
P
< 0.001). Ramosetron was well tolerated by all the study participants.
Conclusions:
Ramosetron is significantly more effective than ondansetron for the control of delayed nausea and vomiting induced by emetogenic cancer chemotherapy.
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1
Afro Middle East Asian symposium on cancer cooperation
Purvish M Parikh, T Raja, L Mula-Hussain, RP Baral, P Ingle, P Narayanan, N Tsikai, MO Baki, N Satyapal, KO Adusei, A Popoola, A Musibi, E Nyaim, U Tsomo, C Opio, A Jamshed, P Reddy
April-June 2014, 3(2):128-131
DOI
:10.4103/2278-330X.130452
PMID
:24818109
This manuscript captures the discussion and recommendations that came out of a special Afro Asian symposium involving 13 countries. Unmet needs and cost-effective solutions with special emphasis on training form the backbone of practical next steps.
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1,066
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2
LETTERS TO EDITOR
Health care in rural India: A lack between need and feed
Sandeep Singh, Sorabh Badaya
April-June 2014, 3(2):143-144
DOI
:10.4103/2278-330X.130483
PMID
:24818117
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947
213
3
Tuberculosis and lung cancer
Somsri Wiwanitkit, Viroj Wiwanitkit
April-June 2014, 3(2):141-141
DOI
:10.4103/2278-330X.130471
PMID
:24818113
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674
243
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NK cell therapy for end-stage cancerous patient: A case study
Junichi Masuyama, Kamon Chaiyasit, Wanviput Sanphasitvong, Viroj Wiwanitkit
April-June 2014, 3(2):143-143
DOI
:10.4103/2278-330X.130480
PMID
:24818116
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691
212
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Finding for epitope within egg shell protein of human liver fluke: A clue for cholangiocarcinoma vaccine development
Viroj Wiwanitkit
April-June 2014, 3(2):142-143
DOI
:10.4103/2278-330X.130476
PMID
:24818115
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697
156
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Severe neurotoxicity due to Vinblastine in Hodgkin lymphoma
Pandalanghat Suresh, Rajan Kapoor, BN Kapur
April-June 2014, 3(2):147-148
DOI
:10.4103/2278-330X.130492
PMID
:24818120
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612
188
1
Choriocarcinomatous differentiation in rectal adenocarcinoma: A rare occurrence
Kavita Mardi, Saurabh Gupta, Neelam Gupta, Vidisha Mahajan
April-June 2014, 3(2):144-145
DOI
:10.4103/2278-330X.130490
PMID
:24818118
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609
188
2
Mucosa-associated lymphoid tissue lymphoma of the ileum in a child presenting as intussusception
Kavita Mardi
April-June 2014, 3(2):146-147
DOI
:10.4103/2278-330X.130491
PMID
:24818119
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604
164
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Myeloma and diabetes mellitus
Sora Yasri, Viroj Wiwanitkit
April-June 2014, 3(2):141-141
DOI
:10.4103/2278-330X.130469
PMID
:24818112
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509
176
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Are results from dosimetric studies sufficient enough to determine the quality of treatment techniques in radiation therapy?
Dinesh Babu Pandey
April-June 2014, 3(2):141-142
DOI
:10.4103/2278-330X.130474
PMID
:24818114
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440
138
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