South Asian Journal of Cancer

ORIGINAL ARTICLE: BREAST CANCER
Year
: 2018  |  Volume : 7  |  Issue : 1  |  Page : 7--10

Estrogen receptor, Progesterone receptor, and human epidermal growth factor receptor-2 status in breast cancer: A retrospective study of 5436 women from a regional cancer center in South India


Rekha Vijay Kumar1, Dipti Panwar1, Usha Amirtham1, Chennagiri Srinivasmurthy Premalata1, Champaka Gopal1, Suma Mysore Narayana1, Geetha Vikram Patil Okaly1, KC Lakshmaiah2, S Krishnamurthy3 
1 Department of Pathology, Kidwai Cancer Institute, Bengaluru, Karnataka, India
2 Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India
3 Department of Surgical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Rekha Vijay Kumar
Department of Pathology, Kidwai Cancer Institute, Bengaluru, Karnataka
India

Aim: The aim of the study was to analyze the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status over 7 years in South Indian women with breast cancer. Further analysis of a subgroup was done to study clinically defined subtypes and the role of preanalytical factors in needle core biopsies (NCBs) and excised specimens. Materials and Methods: This was a retrospective study from January 2010 to December 2016. Patients diagnosed with invasive breast cancer and available immunohistochemistry (IHC) reports of ER, PR, and HER2 status were analyzed. The cases for the year 2016 were analyzed further to observe the impact of preanalytical factors on the IHC staining patterns and surrogate status. Results: A total of 5436 patients were included with a median age of 48 years. Among these, 65% were ≤ 55 years. The overall incidence of hormone receptor (HR)-positive patients was 48%; HER2 positive, 15%; and triple-negative breast cancer (TNBC), 37%. The incidence of HR positive, HER2 positive, and TNBC were 45%, 16%, and 39% and 53%, 13%, and 34% in patients <56 years and over 55 years, respectively (P < 0.001). There was an increase in HR positivity and decrease in TNBCs over time. There was no significant difference in the staining patterns in NCBs and excised specimens. Conclusion: With time, there is an increase in hormone-positive tumors which may be attributed to better IHC techniques and tissue handling. There was no statistical difference in the patterns of ER, PR, and HER2 immunostaining in core biopsy and excised specimens.


How to cite this article:
Kumar RV, Panwar D, Amirtham U, Premalata CS, Gopal C, Narayana SM, Patil Okaly GV, Lakshmaiah K C, Krishnamurthy S. Estrogen receptor, Progesterone receptor, and human epidermal growth factor receptor-2 status in breast cancer: A retrospective study of 5436 women from a regional cancer center in South India.South Asian J Cancer 2018;7:7-10


How to cite this URL:
Kumar RV, Panwar D, Amirtham U, Premalata CS, Gopal C, Narayana SM, Patil Okaly GV, Lakshmaiah K C, Krishnamurthy S. Estrogen receptor, Progesterone receptor, and human epidermal growth factor receptor-2 status in breast cancer: A retrospective study of 5436 women from a regional cancer center in South India. South Asian J Cancer [serial online] 2018 [cited 2018 Sep 23 ];7:7-10
Available from: http://journal.sajc.org/article.asp?issn=2278-330X;year=2018;volume=7;issue=1;spage=7;epage=10;aulast=Kumar;type=0