South Asian Journal of Cancer

ORIGINAL ARTICLE: GASTRO-INTESTINAL & HEPATOBILIARY CANCER
Year
: 2018  |  Volume : 7  |  Issue : 1  |  Page : 27--30

Standard-dose versus high-dose radiotherapy with concurrent chemotherapy in esophageal cancer: A prospective randomized study


Navin Nayan1, M Bhattacharyya1, Vikas K Jagtap2, AK Kalita1, R Sunku1, PS Roy3 
1 Department of Radiation Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
2 Department of Radiation Oncology, NEIGRIHMS, Shillong, Meghalaya, India
3 Department of Medical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India

Correspondence Address:
Dr. Navin Nayan
Department of Radiation Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam
India

Objective: The objective of this study is comparision of local and distant control rates with high-dose versus standard-dose radiotherapy along with concurrent chemotherapy in esophageal cancer – a prospective randomized study. Materials and Methods: Histologically proven Stage I–III patients with carcinoma esophagus were randomized into two groups. One group has been treated with standard-dose radiotherapy, i.e., a total dose of 50.4 Gy (1.8 Gy/day, 28#, 5 days/week). The other group (study arm) has received high-dose radiotherapy, i.e. a total dose of 64.8 Gy (1.8 Gy/day, 36#, 5 days/week). Both groups have received 2 cycles of 3 weekly concurrent chemotherapy (cisplatin 75 mg/m[2] on day 1 and 5-fluorouracil 750 mg/m[2] continuous intravenous infusion over 24 h on day 1–4). Follow-up response evaluation was done by both endoscopy and computed tomography scan after 6–8 weeks and after 2 months thereafter. Results: Out of a total of 28 patients, 68% showed a complete response, 14% showed partial response, and 18% patients developed progressive disease at first and subsequent follow up (median follow-up of 21 months). Among the complete response patients, rates were higher in high-dose group compared to standard-dose radiotherapy group (71% vs. 64%, P = 0.38). Treatment-related toxicities were acceptable in both groups. Conclusion: High-dose radiotherapy with concurrent chemotherapy seems to be more effective with acceptable toxicity in our study. However, further follow-up and large sample size may be required to validate the current study conclusion.


How to cite this article:
Nayan N, Bhattacharyya M, Jagtap VK, Kalita A K, Sunku R, Roy P S. Standard-dose versus high-dose radiotherapy with concurrent chemotherapy in esophageal cancer: A prospective randomized study.South Asian J Cancer 2018;7:27-30


How to cite this URL:
Nayan N, Bhattacharyya M, Jagtap VK, Kalita A K, Sunku R, Roy P S. Standard-dose versus high-dose radiotherapy with concurrent chemotherapy in esophageal cancer: A prospective randomized study. South Asian J Cancer [serial online] 2018 [cited 2019 Nov 19 ];7:27-30
Available from: http://journal.sajc.org/article.asp?issn=2278-330X;year=2018;volume=7;issue=1;spage=27;epage=30;aulast=Nayan;type=0