South Asian Journal of Cancer

HEAD AND NECK CANCER: ORIGINAL ARTICLE
Year
: 2017  |  Volume : 6  |  Issue : 1  |  Page : 15--19

Role of neoadjuvant chemotherapy in advanced carcinoma of the hypopharynx and larynx


Poonam Joshi, Amit Joshi, Vanita Norohna, Pankaj Chaturvedi, Vijay Patil, Jai Prakash Agarwal, Shashikant Juvekar, Kumar Prabhash 
 Department of Medical Oncology, Tata memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Kumar Prabhash
Department of Medical Oncology, Tata memorial Hospital, Mumbai, Maharashtra
India

Background: To assess the response rate and impact of neoadjuvant chemotherapy (NACT) in advanced carcinoma of the hypopharynx and larynx. Materials and Methods: This is a retrospective case series of 80 patients with locally advanced laryngopharynx carcinoma who received NACT from April 2010 to October 2011 at our tertiary care center. The patients received NACT either for achieving resectability or for organ preservation. Results: Majority of the patients (60%) had T4 a disease. Grade 3 and 4 neutropenia was seen in 18%, febrile neutropenia in 4%, mucositis in 4%, diarrhea in 5%, and vomiting in 3% patients. Resectability could be achieved in 34%, and larynx was preserved in 51% patients at a mean follow-up of 13 months. Conclusions: NACT was safe with acceptable toxicity. Majority of the patients who achieved resectability had oropharyngeal involvement. NACT followed by concurrent chemoradiotherapy could provide a high rate of organ preservation.


How to cite this article:
Joshi P, Joshi A, Norohna V, Chaturvedi P, Patil V, Agarwal JP, Juvekar S, Prabhash K. Role of neoadjuvant chemotherapy in advanced carcinoma of the hypopharynx and larynx.South Asian J Cancer 2017;6:15-19


How to cite this URL:
Joshi P, Joshi A, Norohna V, Chaturvedi P, Patil V, Agarwal JP, Juvekar S, Prabhash K. Role of neoadjuvant chemotherapy in advanced carcinoma of the hypopharynx and larynx. South Asian J Cancer [serial online] 2017 [cited 2017 Jul 21 ];6:15-19
Available from: http://journal.sajc.org/article.asp?issn=2278-330X;year=2017;volume=6;issue=1;spage=15;epage=19;aulast=Joshi;type=0