South Asian Journal of Cancer

: 2012  |  Volume : 1  |  Issue : 2  |  Page : 76--77

Fluoride levels and osteosarcoma

Simmi Kharb1, Ravindra Sandhu1, Zile Singh Kundu2 
1 Department of Biochemistry, Pt.BDS PGIMS, Rohtak, India
2 Department of Orthopedics, Pt.BDS PGIMS, Rohtak, India

Correspondence Address:
Simmi Kharb
Department of Biochemistry, Pt.BDS PGIMS, Rohtak

Context: Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma. Aims: The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water. Settings and Design: The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls). Materials and Methods: Serum and drinking water fluoride levels were estimated by ion selective electrode. Statistical analysis used: The data were computed as mean ± SD and Student«SQ»s t test was applied. Results: Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P < 0.05, P < 0.001, respectively). Conclusions: These results suggest a link between fluoride exposure and osteosarcoma.

How to cite this article:
Kharb S, Sandhu R, Kundu ZS. Fluoride levels and osteosarcoma.South Asian J Cancer 2012;1:76-77

How to cite this URL:
Kharb S, Sandhu R, Kundu ZS. Fluoride levels and osteosarcoma. South Asian J Cancer [serial online] 2012 [cited 2020 Mar 28 ];1:76-77
Available from:;year=2012;volume=1;issue=2;spage=76;epage=77;aulast=Kharb;type=0