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Year : 2018  |  Volume : 7  |  Issue : 2  |  Page : 96-101

Practical consensus recommendations on management of HR + ve early breast cancer with specific reference to genomic profiling

1 Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India
2 Department of Medical Oncology, Medanata Hospital, Gurugram, Haryana, India
3 Department of Medical Oncology, HCG Cancer Center, Chennai, Tamil Nadu; Department of Medical Oncology, SMH Curie Cancer Center, New Delhi, India
4 Department of Oncology, Shalby Cancer and Research Institute, Mumbai, Maharashtra, India
5 Department of Medical Oncology, Artemis Hospital, Gurugram, Haryana, India
6 Department or Radiation Oncology, Fortis Hospital, New Delhi, India
7 Department of Medical Oncology, Sarvodaya Hospital, Faridabad, Haryana, India
8 Department of Medicine, INHS Sanjivani, Kochi, Kerala, India
9 Department of Radiation Oncology, RCC, Rohtak, Haryana, India
10 Department of Oncology, Hakim Sanaullah Cancer Center, Baramulla, Jammu and Kashmir, India
11 Department of Medical Oncology, Army Hospital R and R, New Delhi, India
12 Department of Medical Oncology, Rajiv Gandhi Cancer Institute, New Delhi, India

Correspondence Address:
Dr. A Vaid
Department of Medical Oncology, Medanata Hospital, Gurugram, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sajc.sajc_110_18

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Breast cancer is a heterogeneous disease and patients are managed clinically based on ER, PR, HER2 expression, and key risk factors. The use of gene expression assays for early stage disease is already common practice. These tests have found a place in risk stratifying the heterogeneous group of stage I–II breast cancers for recurrence, for predicting chemotherapy response, and for predicting breast cancer-related mortality. Most guidelines for hormone receptor (HR)–positive early breast cancer recommend addition of adjuvant chemotherapy for most women, leading to overtreatment, which causes considerable morbidity and cost. Expert oncologist discussed about strategies of gene expression assays and aid in chemotherapy recommendations for treatment of HR + ve EBC and the expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.

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