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Year : 2017  |  Volume : 6  |  Issue : 3  |  Page : 99-101

Topical vancomycin: Does it reduce surgical site infection in bone tumors?

Department of Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India

Date of Web Publication14-Sep-2017

Correspondence Address:
Ashish Gulia
Department of Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-330X.214572

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Introduction: We retrospectively analyzed a consecutive group of patients operated for bone tumors of extremity and pelvis who received only perioperative antibiotics (Group A) against a similar group that had additional 1 g topical vancomycin sprinkled in the wound before closure (Group B). The aim was to determine if the addition of topical vancomycin decreases the incidence of deep surgical site infection (SSI). Materials and Methods: A total of 221 patients operated between January 2011 and December 2011 were analyzed in Group A and 254 patients operated between April 2012 and March 2013 were analyzed in Group B. Any patient who required operative intervention for wound discharge was considered to be infected. All patients had a 1 year follow-up to determine the incidence of SSI. Results: The overall rate of SSI was 7% (31 of 475 patients). Seventeen (8%) of Group A patients had SSI as against 14 (6 %) of Group B patients (P = 0.337). A subgroup analysis of endoprosthetic reconstructions, internal fixation implants (plates/intramedullary nails), extracorporeal radiation treated bones and strut allografts showed no difference between the two groups of patients. Conclusion: Our data suggest that the addition of topical vancomycin before wound closure in patients operated for bone tumors does not decrease the incidence of SSI. Further investigation of this technique using a case–controlled methodology with an increase in the dose of vancomycin may be warranted.

Keywords: Antibiotics, endoprosthesis, surgical site infection, topical vancomycin

How to cite this article:
Byregowda S, Puri A, Gulia A. Topical vancomycin: Does it reduce surgical site infection in bone tumors?. South Asian J Cancer 2017;6:99-101

How to cite this URL:
Byregowda S, Puri A, Gulia A. Topical vancomycin: Does it reduce surgical site infection in bone tumors?. South Asian J Cancer [serial online] 2017 [cited 2020 Feb 22];6:99-101. Available from:

  Introduction Top

The advances in neoadjuvant chemotherapy, modern surgical techniques, and affordable megaprosthesis have increased the number of complex surgeries we undertake in patients with bone tumors in recent times. Infection remains one of the major complications of these surgeries with literature documenting infection rates varying from 2.2% to 19.5%.[1] This is much higher when compared with the 2% infection rates in conventional joint replacement.[2] The higher infection rate in tumor surgeries can be attributed to their complexity, prolonged duration, extensive blood loss, use of megaprosthesis and allografts, and the immunocompromised status of patients receiving cytotoxic chemotherapeutic agents.[3] Surgical site infections (SSIs) often necessitate multiple surgeries and prolonged antibiotic treatment leading to increased morbidity and cost. An appropriate perioperative antibiotic regimen can play a vital role in reducing SSI, but there is little consensus regarding this when it comes to bone tumor surgeries. Current clinical practice is highly varied, with respect to antibiotic type, duration, and mode of administration.[1]

The presence of hematoma, edema, and ischemic tissue may reduce the efficacy of intravenous (i.v.) antibiotics by preventing access to the local site.[4] The use of topical antibiotics which enable high concentration at the local site with less systemic toxicity thus offers an attractive avenue to help reduce SSI.[5] Recent studies have shown that topical vancomycin reduces SSI in spinal surgeries.[6],[7] The efficacy of similar topical vancomycin has not yet been studied in bone tumor surgeries. The aim of our study was to evaluate the efficacy of additional topical vancomycin in reducing SSI in bone tumor surgeries.

  Materials and Methods Top

We compared the rates of deep surgical wound infection in two groups of consecutive patients operated for bone tumors of the extremity and pelvis. Information was collected from a prospectively maintained database and patient records. Patients who had evidence of infection at the surgical site or a previous history of infection at the surgical site and those who underwent an amputation were excluded from the study. Group A consisting of 236 patients operated between January 2011 and December 2011 had received only perioperative antibiotics as per our department protocol. Group B consisting of 276 patients operated between April 2012 and March 2013 received similar perioperative antibiotics along with additional topical vancomycin at the wound site before closure. Distribution based on the etiology in Group A and Group B are given in [Table 1].
Table 1: Distribution based on etiology in Group A and Group B

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Our antibiotic protocol uses 1.5 g of i.v. cefuroxime 30 min before the incision (vancomycin was used if the patient was allergic to cephalosporins). An additional 1.5 g of cefuroxime infusion is started 45 min after the skin incision for 4 h. If a tourniquet is used, a repeat 1.5 g of cefuroxime bolus after deflation of tourniquet is given in lieu of the infusion. Postoperatively, 500 mg of oral cefuroxime is given twice daily till drain removal. The patients in Group B received an additional 1 g of vancomycin powder topically sprinkled over the wound before closure of the deep fascia after achieving hemostasis. The negative suction drain was kept closed for half an hour after wound closure to prevent the vancomycin from draining out.

As per the Centre for Disease Control and Prevention guidelines for deep SSI (infection occurring within 30 days after the operation if no implant is left in place or within 1 year if implant is in place) patients in both groups were followed up for 1 year to document SSI.[8] Any patient who required surgical intervention for a wound discharge was considered to be infected. Because the vancomycin powder was placed under the deep fascia, only the rate of deep surgical wound infection was analyzed.[9] Deep infection has been shown to be a more accurate parameter for research documentation.[9] In Group A, 12 patients were lost to follow-up and three patients died due to disease. Hence, 221 patients were available for analysis. In Group B, 21 patients were lost to follow-up and one patient died due to disease. Hence, 254 patients were available for analysis.


The data of the present study were collected in the course of common clinical practice and, accordingly, the signed informed consent was obtained from each patient for any surgical and clinical procedure. The study protocol conforms to the ethical guidelines of the “World Medical Association Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjects” adopted by the 18th WMA General Assembly, Helsinki, Finland, June 1964, as revised in Tokyo 2004. No approval of the institutional review committee was needed.

Statistical analysis

All statistical analyses were carried out with the IBM Statistical Package for the Social Sciences (SPSS) version 20, (United states of America). P < 0.05 was considered statistically significant.

  Results Top

A total of 31 patients of the 475 (7%) patients available for analysis developed SSI [Table 2]. Sixteen (52%) of these patients developed an infection within 4 weeks of surgery. A subset analysis of the infection rate based on type of surgery [i.e., endoprosthetic reconstruction, use of internal fixation devices, extracorporeal irradiation and reimplantation, strut allograft is shown in [Table 3].
Table 2: Comparison between two groups

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Table 3: Subset analysis

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  Discussion Top

The rate of SSI following surgery for bone tumor varies from 2.2% to 19.5%.[1] In Hendersons' series, infection was found to be most common cause of failure of megaprosthesis accounting for 34% of cases.[10] SSI after bone tumor surgery can have disastrous consequences. Jeys et al. series of 1261 patients undergoing endoprosthestic replacement documented the risk of amputation being as high as 19% in patients with proven infection.[11]

Local administration of antibiotic at the surgical site before wound closure theoretically achieves high concentration at the local site with less systemic side effects. There is well-established evidence in general orthopedic literature supporting the local use of antibiotics in the form of antibiotic-coated implants and cement beads.[12] Local powdered vancomycin is inexpensive and has a broad coverage against typical organisms responsible for SSI. There are conflicting reports in literature regarding its efficacy in reducing SSI in spinal surgeries. Sweet demonstrated a 2.6% infection rate in posterior dorso-lumbar spine fusion surgeries done with only i.v cephalexin coverage when compared to 0.2% of infection in dorso-lumbar spine fusion surgeries treated with local vancomycin with i.v. cephalexin.[7] A recent meta-analysis also concluded that the local application of vancomycin in spinal injuries reduces SSI, deep incisional SSI, and Staphylococcus aureus SSI.[6] As against this, a prospective randomized study showed no significant reduction in infection rates with use of local vancomycin in spinal surgeries.[5] Martin too in his study failed to show a significant reduction in infection rate with the use of local vancomycin in spinal deformity correction surgeries.[13]

In our study, while the overall infection rate of 7% was comparable to other similar studies. We failed to demonstrate an improvement with the use of additional topical vancomycin (infection rate of 8% in Group A versus 6% in Group B with P = 0.337).[14],[15],[16] This also held true across all the subsets for individual types of surgeries [Table 2].

Although our study is the only study to analyze the effect of additional local vancomycin in SSI in bone tumor surgeries, it does have its limitations. It is a retrospective study which includes mixed etiologies. Our definition of infection included only wounds which required surgical intervention thus possibly missing out on infections which subsided with medical treatment alone. This is unlikely to be a major drawback as deep infection which was our parameter for comparison usually involves reoperation as a standard treatment.[9] We used 1 g of vancomycin powder, which may not be sufficient to prevent infection for these large incisions, and further studies are needed to evaluate whether an increased amount would be more beneficial.[13] The adjutant treatments (chemotherapy and radiotherapy) received between two groups was not significant. Other confounding variables which may contribute to postoperative infections, such as duration of surgery, blood loss, and other medical comorbidities were not evaluated.

In spite of these shortcomings, we feel that this study with relatively large numbers provides a springboard for similar prospective studies that aim to rationalize perioperative antibiotic usage in bone tumor surgeries with a view to reduce SSI.

  Conclusion Top

While our data suggest that the addition of topical vancomycin prior to wound closure in patients operated for bone tumors does not decrease the incidence of SSI further investigation of this technique using a case–controlled methodology with an increase in vancomycin dose may be warranted.


We would like to acknowledge Ms. Saniya Crasto and Ms. Bhanupriya Sandupatla for their help in analyzing the data.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Ghert M, Deheshi B, Holt G, Randall RL, Ferguson P, Wunder J, et al. Prophylactic antibiotic regimens in tumour surgery (PARITY): Protocol for a multicentre randomised controlled study. BMJ Open 2012;2. pii: E002197.  Back to cited text no. 1
Blom AW, Taylor AH, Pattison G, Whitehouse S, Bannister GC. Infection after total hip arthroplasty. The Avon experience. J Bone Joint Surg Br 2003;85:956-9.  Back to cited text no. 2
Nagano S, Yokouchi M, Setoguchi T, Sasaki H, Shimada H, Kawamura I, et al. Analysis of surgical site infection after musculoskeletal tumor surgery: Risk assessment using a new scoring system. Sarcoma 2014;2014:645496.  Back to cited text no. 3
Hanssen AD, Osmon DR, Patel R. Local antibiotic delivery systems: Where are we and where are we going? Clin Orthop Relat Res 2005;437:111-4.  Back to cited text no. 4
Tubaki VR, Rajasekaran S, Shetty AP. Effects of using intravenous antibiotic only versus local intrawound vancomycin antibiotic powder application in addition to intravenous antibiotics on postoperative infection in spine surgery in 907 patients. Spine (Phila Pa 1976) 2013;38:2149-55.  Back to cited text no. 5
Chiang HY, Herwaldt LA, Blevins AE, Cho E, Schweizer ML. Effectiveness of local vancomycin powder to decrease surgical site infections: A meta-analysis. Spine J 2014;14:397-407.  Back to cited text no. 6
Sweet FA, Roh M, Sliva C. Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: Efficacy, drug levels, and patient outcomes. Spine (Phila Pa 1976) 2011;36:2084-8.  Back to cited text no. 7
Centre of Disease Control and Prevention Guidelines for Deep Surgical Site Infection. Available from:  Back to cited text no. 8
Molinari RW, Khera OA, Molinari WJ 3rd. Prophylactic intraoperative powdered vancomycin and postoperative deep spinal wound infection: 1,512 consecutive surgical cases over a 6-year period. Eur Spine J 2012;21 Suppl 4:S476-82.  Back to cited text no. 9
Palumbo BT, Henderson ER, Groundland JS, Cheong D, Pala E, Letson GD, et al. Advances in segmental endoprosthetic reconstruction for extremity tumors: A review of contemporary designs and techniques. Cancer Control 2011;18:160-70.  Back to cited text no. 10
Jeys LM, Grimer RJ, Carter SR, Tillman RM. Risk of amputation following limb salvage surgery with endoprosthetic replacement, in a consecutive series of 1261 patients. Int Orthop 2003;27:160-3.  Back to cited text no. 11
Thonse R, Conway JD. Antibiotic cement-coated nails for the treatment of infected nonunions and segmental bone defects. J Bone Joint Surg Am 2008;90 Suppl 4:163-74.  Back to cited text no. 12
Martin JR, Adogwa O, Brown CR, Bagley CA, Richardson WJ, Lad SP, et al. Experience with intrawound vancomycin powder for spinal deformity surgery. Spine (Phila Pa 1976) 2014;39:177-84.  Back to cited text no. 13
Jeys LM, Grimer RJ, Carter SR, Tillman RM. Periprosthetic infection in patients treated for an orthopaedic oncological condition. J Bone Joint Surg Am 2005;87:842-9.  Back to cited text no. 14
Li X, Moretti VM, Ashana AO, Lackman RD. Perioperative infection rate in patients with osteosarcomas treated with resection and prosthetic reconstruction. Clin Orthop Relat Res 2011;469:2889-94.  Back to cited text no. 15
Natarajan MV, Sivaseelam A, Ayyappan S, Bose JC, Sampath Kumar M. Distal femoral tumours treated by resection and custom mega-prosthetic replacement. Int Orthop 2005;29:309-13.  Back to cited text no. 16


  [Table 1], [Table 2], [Table 3]


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