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LETTER TO THE EDITOR
Year : 2017  |  Volume : 6  |  Issue : 2  |  Page : 63-78

Verrucous carcinoma of foot at an unusual site: Lessons to be learnt


Department of General Surgery, Stanley Medical College, Chennai, Tamil Nadu, India

Date of Web Publication22-Jun-2017

Correspondence Address:
K Aravind Menon
Department of General Surgery, Stanley Medical College, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-330X.208839

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How to cite this article:
Nagarajan D, Chandrasekhar M, Jebakumar J, Menon K A. Verrucous carcinoma of foot at an unusual site: Lessons to be learnt. South Asian J Cancer 2017;6:63-78

How to cite this URL:
Nagarajan D, Chandrasekhar M, Jebakumar J, Menon K A. Verrucous carcinoma of foot at an unusual site: Lessons to be learnt. South Asian J Cancer [serial online] 2017 [cited 2017 Oct 20];6:63-78. Available from: http://journal.sajc.org/text.asp?2017/6/2/63/208839

Dear Editor,

Verrucous carcinoma is a rare variant of squamous cell carcinoma occurring in the feet. It is a low-grade tumor commonly arising from areas of chronic trauma and irritation. These lesions often tend to be ignored by patients and clinicians who treat it like any other nonhealing ulcer. When diagnosed and treated early, it is fully curable. Late intervention leads to the local destruction of tissues and need of extensive excision that may result in amputations. Thus, this case is reported to highlight how a chronically neglected unidentified verrucous carcinoma of the foot could be managed successfully with excellent cosmesis and function due to timely intervention.

A 63-year-old daily wage laborer presented with the complaints of a nonhealing ulcer over the dorsum of the right foot, for the past 30 years. [Figure 1]. Thirty years back, he developed the ulcer from a blister on the dorsum of his right foot which he acquired while working, sitting with his legs crossed. He was asymptomatic for the past 30. years though the ulcer did not heal with routine treatment. For the past 4. months, there is a foul smelling discharge from the ulcer with associated pricking pain which brought him to us. On examination, he has an irregular warty growth over the dorsum right foot arising from an ulcer with associated foul smelling discharge and tenderness to palpate. Suspecting a malignancy clinically, we did magnetic resonance imaging. (MRI) of the foot with wedge biopsy. Imaging revealed only soft tissue lesion with no bony involvement. Biopsy revealed bulbous proliferation of neoplastic squamous cells with nuclear pleomorphism and keratin pearl formation with the impression of verrucous carcinoma. [Figure 2]. Wide local excision with assessment of margin status was done. [Figure 3] and [Figure 4]. The raw area postexcision was covered with split thickness skin graft. [Figure 5]. The patient was discharged with a fully functional limb and excellent cosmesis.
Figure 1: Verrucous carcinoma dorsum of foot

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Figure 2: Histopathological picture

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Figure 3: Postwide local excision

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Figure 4: Granulated raw area after 2 weeks

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Figure 5: After split skin grafting

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Verrucous carcinoma of the foot is a relatively uncommon malignancy, usual site being the ball of the great toe.[1] It usually develops as a chronic nonhealing ulcer at the sites of constant trauma and local irritation at weight bearing areas and later transforms into malignancy. It is due to the same reason these lesions are often mismanaged as an infective ulcer or a viral wart for years before the patient turns up with a florid growth with surrounding infiltration.

The term verrucous carcinoma was coined by Ackerman in 1948, and Aird et al.[2] described the uncommon form of verrucous carcinoma of foot termed as epithelioma cuniculatum in 1954. Other sites of verrucous carcinoma include the oral cavity and anogenital region. Epithelioma cuniculatum usually affects older males, with a mean age of 52.60. years.[3] Although it is a low grade variant of squamous cell carcinoma which never metastasizes, it is notorious to cause local infiltration and destruction of the local structures through its chronic course.[3] Metastasis from verrucous carcinoma has been reported only five times in literature, being lymph nodes in all and lung in one patient.[4],[5] Though plantar verrucous carcinoma is common in the soles, it can develop even on dorsal surface in areas of occupational friction as is evident from the above-mentioned case.

Two cases of bilateral epithelioma cuniculatum have been described in literature. One patient was treated successfully with excision and selective toe amputation.[6] The other underwent bilateral forefoot amputations.[7]

Though human papilloma virus–types 6, 11, 16, and 18 have been implicated in the pathogenesis of verrucous carcinoma, most authors could not substantiate the presence of HPV in specimens.[8],[9]

Radiographs of the involved area to look for bony involvement are necessary. Computerized tomographs can identify bony erosions in better way than MRI scans. The current treatment for verrucous carcinoma is surgical excision–a wide local excision rather than a marginal excision since the margins are not always apparent intraoperatively. It is a locally malignant destructive tumor; hence, the presence of bony involvement on imaging presses the need for amputation. Inability to provide adequate tumor-free margins may result in a local recurrence of the tumor and multiple attempts at excision resulting in recurrence warrants amputation.[4],[10] Other therapeutic modalities include topical chemotherapy, electrocautery, cryotherapy, and laser therapy, but all have high recurrence rates. Radiotherapy is not recommended due to possibility of malignant transformation to squamous cell carcinoma. The long-term prognosis is good with surgical excision with cure rates up to 99%.[11]

This case here had a verrucous carcinoma on the dorsum of foot which is an unusual site without any mention in the literature. The patient was a daily wage laborer who used to work sitting with his legs crossed. Thus, we presume that his occupational posture causing chronic irritation to the dorsum of his feet was the predisposing factor for the lesion. Wide local excision with delayed skin cover after confirmation of margin status provides excellent cosmesis as seen here.

Though an uncommon lesion, the entity of verrucous carcinoma arising from areas of chronic trauma needs attention especially among primary physicians. When diagnosed early, surgical excision can prevent morbidity and disability in these patients. The misdiagnosis of these lesions commonly leads to delayed treatment for years and progression of the disease to local infiltration before the patient presents to the surgeon.

Hence, any nonhealing ulcer of the foot should not be neglected, and focus of malignancy needs to be ruled out.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Schwartz RA. Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol 1995;32:1-21.  Back to cited text no. 1
[PUBMED]    
2.
Aird I, Johnson HD, Lennox B, Stansfeld AG. Epithelioma cuniculatum: A variety of squamous carcinoma peculiar to the foot. Br J Surg 1954;42:245-50.  Back to cited text no. 2
[PUBMED]    
3.
Pempinello C, Bova A, Pempinello R, Luise R, Iannaci G. Verrucous carcinoma of the foot with bone invasion: A case report. Case Rep Oncol Med 2013;2013:135307.  Back to cited text no. 3
[PUBMED]    
4.
McKee PH, Wilkinson JD, Black MM, Whimster IW. Carcinoma (epithelioma) cuniculatum: A clinico-pathological study of nineteen cases and review of the literature. Histopathology 1981;5:425-36.  Back to cited text no. 4
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5.
Kao GF, Graham JH, Helwig EB. Carcinoma cuniculatum (verrucous carcinoma of the skin): A clinicopathologic study of 46 cases with ultrastructural observations. Cancer 1982;49:2395-403.  Back to cited text no. 5
[PUBMED]    
6.
Seehafer JR, Rahman D, Soderstrom CW. Epithelioma cuniculatum: Verrucous carcinoma of the foot. Cutis 1979;23:287-90.  Back to cited text no. 6
[PUBMED]    
7.
Suen K, Wijeratne S, Patrikos J. An unusual case of bilateral verrucous carcinoma of the foot (epithelioma cuniculatum). J Surg Case Rep 2012;12:1-3.  Back to cited text no. 7
    
8.
Coldiron BM, Brown FC, Freeman RG. Epithelioma cuniculatum (carcinoma cuniculatum) of the thumb: A case report and literature review. J Dermatol Surg Oncol 1986;12:1150-5.  Back to cited text no. 8
[PUBMED]    
9.
Miller SB, Brandes BA, Mahmarian RR, Durham JR. Verrucous carcinoma of the foot: A review and report of two cases. J Foot Ankle Surg 2001;40:225-31.  Back to cited text no. 9
[PUBMED]    
10.
Affleck AG, Leach IH, Littlewood SM. Carcinoma cuniculatum arising in focal plantar keratoderma. Dermatol Surg 2007;33:745-8.  Back to cited text no. 10
[PUBMED]    
11.
Lesic A, Nikolic M, Sopta J, Starcevic B, Bumbasirevic M, Atkinson HD. Verrucous carcinoma of the foot: A case report. J Orthop Surg (Hong Kong) 2008;16:251-3.  Back to cited text no. 11
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

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