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LETTER TO EDITOR
Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 48-49

Spontaneous rupture of renal cell carcinoma: A series of three cases


Department of Urology, Asian Institute of Nephrology and Urology, Hyderabad, Andhra Pradesh, India

Date of Web Publication23-Jan-2015

Correspondence Address:
Bhuvanesh Nanjappa
Department of Urology, Asian Institute of Nephrology and Urology, Hyderabad, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-330X.149956

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How to cite this article:
Nanjappa B, Chiruvella M, Reddy PC, Ragoori D, Bendigeri MT. Spontaneous rupture of renal cell carcinoma: A series of three cases. South Asian J Cancer 2015;4:48-9

How to cite this URL:
Nanjappa B, Chiruvella M, Reddy PC, Ragoori D, Bendigeri MT. Spontaneous rupture of renal cell carcinoma: A series of three cases. South Asian J Cancer [serial online] 2015 [cited 2019 Oct 23];4:48-9. Available from: http://journal.sajc.org/text.asp?2015/4/1/48/149956

Dear Editor,

Renal cell carcinoma (RCC) is the most common malignant tumor of the kidney. Presentation of RCC as spontaneous renal hemorrhage is uncommon. It is possible to determine the etiology by contrast-enhanced computed tomography (CECT) or magnetic resonance imaging (MRI); sometimes it presents a diagnostic and therapeutic dilemma. A variety of causes (neoplasm, vascular abnormality, and renal parenchymal disease) have been described. Occult RCC is considered to comprise up to 50% of causative etiology.

A 49-year-old man presented with left flank pain. Ultrasound revealed a large left perinephric hematoma measuring 6 × 7 cm. After initial resuscitation and blood transfusion, CECT confirmed a perinephric hematoma. Main renal vessels were normal, delayed images showed no extravasation [Figure 1]a and b. Patient was taken up for emergency exploration. After vascular control, a large perinephric hematoma and a midpolar tumor measuring 4 × 4 cm was seen. Subsequently, nephrectomy was performed. Pathology revealed papillary RCC [Figure 2].
Figure 1: Contrast - enhanced computed tomography images showing left perinephric hematoma with intact renal arteries in the arterial phase. The delayed image showing left perinephric hematoma with a breach in the parenchyma at the level of the midpole

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Figure 2: Gross photograph showing tumor in lower pole with extensive hemorrhage on cut surface. Histomicrophotograph showing tumor cells in clusters (H and E, ×100)

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A 43-year-old teacher, hypertensive, presented with left flank pain since a month. CECT showed a perinephric hematoma of the left kidney. A large perinephric hematoma was seen compressing the kidney during exploration. After evacuation of clot, a tumor was seen in the upper pole. This patient underwent radical nephrectomy. The histopathology was consistent with clear cell type of RCC.

A 25-year-old male engineer, was found to have a complex cyst in the right kidney during evaluation of hypertension. The cyst contents showed enhancement on the CECT. MRI showed features of solid contents within the cyst. Nephrectomy and partial nephrectomy were offered. Patient opted for radical nephrectomy. Histopathology revealed clear cell RCC.

RCCs are now discovered as 'incidentalomas' in contrast to the classic presentation. [1] The spontaneous bleeding of the kidney (subcapsular and/or perinephric space) was first described by Carl Reinhold August Wunderlich. [2] Wunderlich syndrome is uncommon and most of the causes are benign. [3] In a review, 70% were due to benign causes, including vascular disease, infection, and neoplasia. Neoplastic causes accounted for 61.2% of these cases. [4]

Immediate surgery [5] or embolization are the options [6] based on patient's general condition. Once the patient's condition is stabilized, embolization is prudent. Else an immediate exploration seems appropriate.

CECT is the most reliable modality in diagnosing retroperitoneal hemorrhage and RCC. [7] However, the efficiency of CT to diagnose RCC at the time of bleeding is an area of concern. Kendall et al., found that 60% of subjects showed RCC undiagnosed at the time of initial CT. [8] After initial CT evaluation, radical nephrectomy is the treatment of choice for tumors diagnosed as malignant and embolization may be the modality of choice for benign conditions. If malignancy is found on the follow-up CT, delayed surgery would affect the resectability, clinical staging, and outcomes. [9],[10]

Wunderlich syndrome is a rare phenomenon that usually occurs due tobenign causes, but a significant proportion, are associated with malignancy. Underlying malignancy may be missed on initial CT. One must, therefore, be aware of the possibility of a malignant etiology. The cornerstone of successful management includes initial resuscitation, embolization, and nephrectomy. Where RCC is diagnosed on initial CT, immediate embolization or early resection, depending on the patient's condition, is a safe and reasonable approach.

 
  References Top

1.
Rousseau T, Peyret C, Zerbib M, Thiounn N, Flam T, Debre B. Circumstances of the detection of kidney cancer. Current part of accidental discoveries. J Urol (Paris) 1994;100:189-95.  Back to cited text no. 1
    
2.
Wunderlich CR. Handbuch der Pathologie und Therapie. 2 nd ed. Stuttgart: Ebner and Seubert;1856.  Back to cited text no. 2
    
3.
Daskalopoulos G, Karyotis I, Heretis I, Anezinis P, Mavromanolakis E, Delakas D. Spontaneous perirenal hemorrhage: A 10-year experience at our institution. Int Urol Nephrol 2004;36:15-9.  Back to cited text no. 3
    
4.
Zhang JQ, Fielding JR, Zou KH. Etiology of spontaneous perirenal hemorrhage: A meta-analysis. J Urol 2002;167:1593-6.  Back to cited text no. 4
    
5.
Hao Lw, Lin CM, Tsai SH. Spontaneous hemorrhagic angiomyolipoma present with massive hematuria leading to urgent nephrectomy. Am J Emerg Med 2008;26:249.  Back to cited text no. 5
    
6.
Pummer K, Lammer J, Wandschneider G, Primus G. Renal cell carcinoma presenting as spontaneous retroperitoneal haemorrhage. Int Urol Nephrol 1990;22:307-11.  Back to cited text no. 6
    
7.
Sebastia MC, Perez-Molina MO, Alvarez-Castells A, Quiroga S, Pallisa E. CT evaluation of underlying cause in spontaneous subcapsular and perirenal hemorrhage. Eur Radiol 1997;7:686-90.  Back to cited text no. 7
    
8.
Kendall AR, Senay BA, Coll ME. Spontaneous subcapsular renal hematoma: Diagnosis and management. J Urol 1988;139:246-50.  Back to cited text no. 8
    
9.
Hashimoto T, Yamamoto S, Togo Y, Ueda Y, Higuchi Y, Maruyama T, et al. Spontaneous rupture of renal cell carcinoma: A case report. Hinyokika Kiyo 2007;53:49-52.  Back to cited text no. 9
    
10.
Nakai M, Nakamura N. A case report of spontaneous rupture of renal cell carcinoma difficult to be distinguished from angiomyolipoma. Hinyokika Kiyo 2003;49:99-101.  Back to cited text no. 10
    


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