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Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 43-47

Serum zinc as a prognostic indicator in locally advanced cancer cervix patients receiving chemo-irradiation: A pilot study

1 Department of Radiation Oncology, Artemis Health Institute, Sector 51, Gurgaon, Haryana, India
2 Department of Radiation Oncology, AIIMS, New Delhi, India
3 Department of Radiation Oncology, RGCI and RC, New Delhi, India

Correspondence Address:
Vivek Tiwari
Department of Radiation Oncology, Artemis Health Institute, Sector 51, Gurgaon, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-330X.126520

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Objective: To evaluate the prognostic significance of serum Zinc (S.Zn) in locally advanced cancer cervix (LACC) patients treated with chemo-irradiation. Materials and Methods: S.Zn values in 34 females with histopathologically (HP) proven LACC (>/= stage II B) were prospectively measured using atomic absorption spectrophotometer pre- and post-treatment. Thirty-four age- and sex-matched healthy individuals were also evaluated for the parameter during the course of the study. After completion of treatment, the patients were divided into 2 groups based on the response, 1 - Complete response (CR) and 2 - Partial/No response (PR/NR). These groups were compared based on the observations of the studied parameter. Results: The mean post-treatment S.Zn values were significantly higher in group 1 as compared to group 2 (P < 0.05). Conclusion: In our study, patients achieving CR had higher mean levels of S.Zn compared to patients achieving PR/NR. We advocate further in-depth studies to evaluate the role of S.Zn in the prognosis of LACC patients treated with chemo-irradiation.

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